Genome-Wide Association Study of Receptive Language Ability of 12-Year-Olds

Autor/inn/en	Harlaar, Nicole; Meaburn, Emma L.; Hayiou-Thomas, Marianna E.; Davis, Oliver S. P.; Docherty, Sophia; Hanscombe, Ken B.; Haworth, Claire M. A.; Price, Thomas S.; Trzaskowski, Maciej; Dale, Philip S.; Plomin, Robert
Titel	Genome-Wide Association Study of Receptive Language Ability of 12-Year-Olds
Quelle	In: Journal of Speech, Language, and Hearing Research, 57 (2014) 1, S.96-105 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1092-4388
DOI	10.1044/1092-4388(2013/12-0303)
Schlagwörter	Receptive Language; Genetics; Individual Differences; Twins; Early Adolescents; Heredity; Language Skills; Multivariate Analysis; Correlation; Regression (Statistics); Replication (Evaluation); Foreign Countries; United Kingdom (England); United Kingdom (Wales); Wechsler Intelligence Scale for Children + Suchen Sie Ihr Suchwort? Rezeptive Kommunikationsfähigkeit; Humangenetik; Individueller Unterschied; Twin; Zwilling; Erblichkeit; Language skill; Sprachkompetenz; Multivariate Analyse; Korrelation; Regression; Regressionsanalyse; Ausland
Abstract	Purpose: Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the heritability of receptive language ability using a "genome-wide association" approach. Method: The authors administered 4 Internet-based measures of receptive language (vocabulary, semantics, syntax, and pragmatics) to a sample of 2,329 twelve-year-olds for whom DNA and genome-wide genotyping were available. Nearly 700,000 single-nucleotide polymorphisms (SNPs) and 1 million imputed SNPs were included in a genome-wide association analysis of receptive language composite scores. Results: No SNP associations met the demanding criterion of genome-wide significance that corrects for multiple testing across the genome ( p < 5 × 10[superscript -8]). The strongest SNP association did not replicate in an additional sample of 2,639 twelve-year-olds. Conclusions: These results indicate that individual differences in receptive language ability in the general population do not reflect common genetic variants that account for more than 3% of the phenotypic variance. The search for genetic variants associated with language skill will require larger samples and additional methods to identify and functionally characterize the full spectrum of risk variants. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10