Growth Factor Signaling and Memory Formation: Temporal and Spatial Integration of a Molecular Network

Autor/inn/en	Kopec, Ashley M.; Carew, Thomas J.
Titel	Growth Factor Signaling and Memory Formation: Temporal and Spatial Integration of a Molecular Network
Quelle	In: Learning & Memory, 20 (2013) 10, S.531-539 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.031377.113
Schlagwörter	Brain; Neurological Organization; Adults; Memory; Brain Hemisphere Functions; Spatial Ability; Molecular Structure; Time Perspective + Suchen Sie Ihr Suchwort? Gehirn; Gedächtnis; Räumliches Vorstellungsvermögen; Zeitbezug
Abstract	Growth factor (GF) signaling is critically important for developmental plasticity. It also plays a crucial role in adult plasticity, such as that required for memory formation. Although different GFs interact with receptors containing distinct types of kinase domains, they typically signal through converging intracellular cascades (e.g., Ras-MEK-MAPK) to mediate overlapping functional endpoints. Several GFs have been implicated in memory formation, but due to a high level of convergent signaling, the unique contributions of individual GFs as well as the interactions between GF signaling cascades during the induction of memory is not well known. In this review, we highlight the unique roles of specific GFs in dendritic plasticity, and discuss the spatial and temporal profiles of different GFs during memory formation. Collectively, the data suggest that the roles of GF signaling in long-lasting behavioral and structural plasticity may be best viewed as interactive components in a complex molecular network. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10