Prescription Errors in Older Individuals with an Intellectual Disability: Prevalence and Risk Factors in the Healthy Ageing and Intellectual Disability Study

Autor/inn/en	Zaal, Rianne J.; van der Kaaij, Annemieke D. M.; Evenhuis, Heleen M.; van den Bemt, Patricia M. L. A.
Titel	Prescription Errors in Older Individuals with an Intellectual Disability: Prevalence and Risk Factors in the Healthy Ageing and Intellectual Disability Study
Quelle	In: Research in Developmental Disabilities: A Multidisciplinary Journal, 34 (2013) 5, S.1656-1662 (7 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0891-4222
DOI	10.1016/j.ridd.2013.02.005
Schlagwörter	Living Standards; Body Composition; Incidence; Predictor Variables; Mental Retardation; Patients; Older Adults; Drug Therapy; Risk; Age; Sex; Aging (Individuals); Graduate Students; Pharmaceutical Education; Pharmacy; Health Personnel; Multivariate Analysis; Intervention; Physiology; Correlation + Suchen Sie Ihr Suchwort? Lebensstandard; Vorkommen; Prädiktor; Geistige Behinderung; Patient; Älterer Erwachsener; Risiko; Alter; Lebensalter; Geschlecht; Geschlechtsverkehr; Aging; Altern; Graduate Study; Student; Students; Aufbaustudium; Graduiertenstudium; Hauptstudium; Studentin; Apotheke; Medizinisches Personal; Multivariate Analyse; Physiologie; Korrelation
Abstract	Prescribing pharmacotherapy for older individuals with an intellectual disability (ID) is a complex process, possibly leading to an increased risk of prescription errors. The objectives of this study were (1) to determine the prevalence of older individuals with an intellectual disability with at least one prescription error and (2) to identify potential risk factors for these prescription errors (age, gender, body mass index (BMI), frailty index, level of intellectual disability and living situation). The study population consisted of 600 older ([greater than or equal to]50 years) individuals with an ID using one or more drugs who were randomly selected from the study cohort of the Healthy Ageing and Intellectual Disability (HA-ID) Study. The medication used at the time of measurement was screened for errors by a hospital pharmacist/clinical pharmacologist and a Master's student pharmacy using consensus methodology. Participants with one or more prescription errors were compared to participants without prescription errors by multivariate logistic regression to identify potential risk factors. The prevalence of individuals with one or more prescription errors was 47.5% (285 of 600 individuals; 95% confidence interval (CI) 43-52%). Relevant errors, defined as errors that actually do require a change of pharmacotherapy, were identified in 26.8% of the individuals (161 of 600 individuals; 95% CI 23-30%). Higher age (adjusted odds ratio (OR[subscript adj]) 1.03; 95% CI 1.01-1.06), less severe intellectual disability (moderate: OR[subscript adj] 0.48; 95% CI 0.31-0.74 and severe: OR[subscript adj] 0.56; 95% CI 0.32-0.98), higher BMI (OR[subscript adj] 1.04; 95% CI 1.01-1.08), higher frailty index (0.39-0.54: OR[subscript adj] 2.4; 95% CI 1.21-4.77 and greater than or equal to 0.55: OR[subscript adj] 3.4; 95% CI 1.03-11.02), polypharmacy (OR[subscript adj] 8.06; 95% CI 5.59-11.62) and use of medicines acting on the central nervous system (OR[subscript adj] 3.34; 95% CI 2.35-4.73) were independently associated with the occurrence of prescription errors. Interventions targeted to high risk patients should be designed and implemented to improve pharmacotherapy in older individuals with an intellectual disability. (Contains 5 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10