Activation of BDNF Signaling Prevents the Return of Fear in Female Mice

Autor/inn/en	Baker-Andresen, Danay; Flavell, Charlotte R.; Li, Xiang; Bredy, Timothy W.
Titel	Activation of BDNF Signaling Prevents the Return of Fear in Female Mice
Quelle	In: Learning & Memory, 20 (2013) 5, S.237-240 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.029520.112
Schlagwörter	Animals; Fear; Females; Gender Differences; Posttraumatic Stress Disorder; Anxiety Disorders; Resistance (Psychology); Learning Processes; Inhibition; Genetics; Biochemistry + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Furcht; Weibliches Geschlecht; Geschlechterkonflikt; Resistenz; Learning process; Lernprozess; Hemmung; Humangenetik; Biochemie
Abstract	There are significant sex differences in vulnerability to develop fear-related anxiety disorders. Females exhibit twice the rate of post-traumatic stress disorder (PTSD) as males and sex differences have been observed in fear extinction learning in both humans and rodents, with a failure to inhibit fear emerging as a precipitating factor in the development of PTSD. Here we report that female mice are resistant to fear extinction, and exhibit increased DNA methylation of "Bdnf" exon IV and a concomitant decrease in mRNA expression within the medial prefrontal cortex. Activation of BDNF signaling by the trkB agonist 7,8-dihydroxyflavone blocks the return of fear in female mice after extinction training, and thus represents a novel approach to treating fear-related anxiety disorders that are characterized by a resistance to extinction and increased propensity for renewal. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10