GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: Elucidating potential anti-atherothrombotic targets in obesity.

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Autor/Urheber	Barrachina, María N; Sueiro, Aurelio M; Izquierdo, Irene; Hermida-Nogueira, Lidia; Guitián, Esteban; Casanueva, Felipe F; Farndale, Richard; Moroi, Masaaki; Jung, Stephanie; Pardo, María; García, Ángel
Institution	Elsevier; Atherosclerosis
Titel	GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: Elucidating potential anti-atherothrombotic targets in obesity.
Quelle	In: doi:10.17863/CAM.35869(2019) PDF als Volltext kostenfreie Datei
Sprache	englisch
Dokumenttyp	online; Zeitschriftenaufsatz
DOI	10.17863/CAM.35869
Schlagwörter	Blood Platelets; Humans; Obesity; Platelet Membrane Glycoproteins; Body Mass Index; Case-Control Studies; Signal Transduction; Phosphorylation; Platelet Activation; Platelet Aggregation; Adolescent; Adult; Female; Male; Phospholipase C gamma; Young Adult
Abstract	Abstract: Background and aims: Platelets play a fundamental role in the increased atherothrombotic risk related to central obesity since they show hyperactivation and lower sensitivity to antiplatelet therapy in obese patients. The main goal of this study was to identify platelet biomarkers related to the risk of suffering atherothrombosis in obese patients, confirm platelet activation levels in these patients, and identify altered activation pathways. ; In addition to the British Heart Foundation, the following are the sources of funding: Spanish Ministry of Economy and Competitiveness (MINECO) [grant No. SAF2016-79662-R], co-funded by the European Regional Development Fund (ERDF). Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (Centro Singular de investigación de Galicia accreditation 2016-2019, ED431G/05) Regional Development Fund (ERDF)
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