Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning in rodents.

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Autor/Urheber	Fowler, Stephanie Wade
Titel	Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning in rodents.
Quelle	University of Missouri--Columbia (2012) PDF als Volltext kostenfreie Datei
Sprache	englisch
Dokumenttyp	online; Monographie
DOI	10.32469/10355/35152
Schlagwörter	learning processes; mGlu5 receptors; aversive learning
Abstract	Title from PDF of title page (University of Missouri--Columbia, viewed on May 13, 2013). ; The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. ; Dissertation advisor: Dr. Todd R. Schachtman ; Includes bibliographical references. ; Vita. ; Ph. D. University of Missouri--Columbia 2012. ; "May 2012" ; Metabotropic glutamate receptor 5 (mGlu5) has been implicated in a variety of learning processes and is important for aversive learning tasks. The present studies used an mGlu5 receptor positive allosteric modulator, 2-cyano-N-(1,3 diphenyl-1H-hyrazol-5-yl)benzamide (CDPPB) to characterize the importance of mGlu5 receptors in aversively- and appetitively-motivated spatial learning. CDPPB, administered prior to 5 daily training sessions in the Barnes maze (Experiment 1) did not significantly enhance acquisition of the task. However, in a second experiment CDPPB (30 mg/kg) significantly enhanced performance compared to vehicle-treated controls during 3 days of reversal learning and had a significant effect on proportion search strategy used. Additionally, CDPPB (30 mg/kg), delivered 20 min prior to 5 daily training sessions (of Experiment 3) enhanced the delay rats were able to withstand in the appetitively-motivated delayed alternation version of the T-maze. The present results emphasize the role of mGlu5 receptors in spatial learning tasks, and demonstrate mGlu5 receptors are important for learning in appetitive, as well as aversive, tasks. ; Includes bibliographical references
Anmerkungen	University of Missouri--Columbia. Graduate School. Theses and Dissertations.; 872569195
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