Mortality Due to Cystic Fibrosis over a 36-Year Period in Spain: Time Trends and Geographic Variations.

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Autor/Urheber	Villaverde-Hueso, Ana; Sanchez-Diaz, German; Molina-Cabrero, Francisco J; Gallego, Elisa; Posada de la Paz, Manuel; Alonso-Ferreira, Veronica
Institution	MDPI
Titel	Mortality Due to Cystic Fibrosis over a 36-Year Period in Spain: Time Trends and Geographic Variations.
Quelle	In: Publisher's version; info:eu_repo/grantAgreement/ES/TPY1238/15; info:eu_repo/grantAgreement/ES/FPU14/03914; Int J Environ Res Public Health. 2019 Jan 4;16(1). pii: E119.; 1660-4601; 30621191; doi:10.3390/ijerph16010119; International journal of environmental research and public health(2019) PDF als Volltext kostenfreie Datei
Sprache	englisch
Dokumenttyp	online; Zeitschriftenaufsatz
DOI	10.3390/ijerph16010119
Schlagwörter	cystic fibrosis; geographic analysis; mortality trends; population-based mortality; Adolescent; Adult; Aged; 80 and over; Child; Preschool; Female; Geography; Humans; Infant; Newborn; Male; Middle Aged; Mortality; Spain; Young Adult
Abstract	The aim of this study is to analyze population-based mortality attributed to cystic fibrosis (CF) over 36 years in Spain. CF deaths were obtained from the National Statistics Institute, using codes 277.0 from the International Classification of Diseases (ICD) ninth revision (ICD9-CM) and E84 from the tenth revision (ICD10) to determine the underlying cause of death. We calculated age-specific and age-adjusted mortality rates, and time trends were assessed using joinpoint regression. The geographic analysis by district was performed by standardized mortality ratios (SMRs) and smoothed-SMRs. A total of 1002 deaths due to CF were identified (50.5% women). Age-adjusted mortality rates fell by -0.95% per year between 1981 and 2016. The average age of death from CF increased due to the annual fall in the mortality of under-25s (-3.77% males, -2.37% females) and an increase in over-75s (3.49%). We identified districts with higher than expected death risks in the south (Andalusia), the Mediterranean coast (Murcia, Valencia, Catalonia), the West (Extremadura), and the Canary Islands. In conclusion, in this study we monitored the population-based mortality attributed to CF over a long period and found geographic differences in the risk of dying from this disease. These findings complement the information provided in other studies and registries and will be useful for health planning. ; This research was funded by the Instituto de Salud Carlos III, Spanish Strategy Action for Health (AESI), project TPY1238/15. The author G.S.D. received a research grant from the Spanish Ministry of Education, Culture, and Sport, FPU14/03914. ; Sí
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