Distributed Learning Episodes Create a Context Fear Memory outside the Hippocampus That Depends on Perirhinal and Anterior Cingulate Cortices

Autor/inn/en	Shepherd, Elizabeth H.; Fournier, Neil M.; Sutherland, Robert J.; Lehmann, Hugo
Titel	Distributed Learning Episodes Create a Context Fear Memory outside the Hippocampus That Depends on Perirhinal and Anterior Cingulate Cortices
Quelle	In: Learning & Memory, 28 (2021) 11, S.405-413 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Brain Hemisphere Functions; Neurological Impairments; Fear; Memory; Conditioning; Context Effect + Suchen Sie Ihr Suchwort? Neurodegenerative Erkrankung; Furcht; Gedächtnis
Abstract	Damage to the hippocampus (HPC) typically causes retrograde amnesia for contextual fear conditioning. Repeating the conditioning over several sessions, however, can eliminate the retrograde amnesic effects. This form of reinstatement thus permits modifications to networks that can support context memory retrieval in the absence of the HPC. The present study aims to identify cortical regions that support the nonHPC context memory. Specifically, the contribution of the perirhinal cortex (PRH) and the anterior cingulate cortex (ACC) were examined because of their established importance to context memory. The findings show that context memories established through distributed reinstatement survive damage limited only to the HPC, PRH, or ACC. Combined lesions of the HPC and PRH, as well as the HPC and ACC, caused retrograde amnesia, suggesting that network modifications in the PRH and ACC enable context fear memories to become resistant to HPC damage. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01