A Subcortical Oscillatory Network Contributes to Recovery of Hand Dexterity after Spinal Cord Injury

Autor/inn/en	Nishimura, Yukio; Morichika, Yosuke; Isa, Tadashi
Titel	A Subcortical Oscillatory Network Contributes to Recovery of Hand Dexterity after Spinal Cord Injury
Quelle	In: Brain, 132 (2009) 3, S.709-721 (13 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0006-8950
DOI	10.1093/brain/awn338
Schlagwörter	Neurological Impairments; Brain; Human Body; Psychomotor Skills; Cognitive Development; Cognitive Processes; Head Injuries; Learning Processes + Suchen Sie Ihr Suchwort? Neurodegenerative Erkrankung; Gehirn; Menschlicher Körper; Psychomotorische Aktivität; Kognitive Entwicklung; Cognitive process; Kognitiver Prozess; Kopfverletzung; Learning process; Lernprozess
Abstract	Recent studies have shown that after partial spinal-cord lesion at the mid-cervical segment, the remaining pathways compensate for restoring finger dexterity; however, how they control hand/arm muscles has remained unclear. To elucidate the changes in dynamic properties of neural circuits connecting the motor cortex and hand/arm muscles, we investigated the cortico- and inter-muscular couplings of activities throughout the recovery period after the spinal-cord lesion. Activities of antagonist muscle pairs showed co-activation and oscillated coherently at frequencies of 30-46 Hz (gamma-band) by 1-month post-lesion. Such gamma-band inter-muscular coupling was not observed pre-lesion, but emerged and was strengthened and distributed over a wide range of hand/arm muscles along with the recovery. Neither the beta-band (14-30 Hz) cortico-muscular coupling observed pre-lesion nor a gamma-band oscillation was observed in the motor cortex post-lesion. We propose that a subcortical oscillator commonly recruits hand/arm muscles, via remaining pathways such as reticulospinal and/or propriospinal tracts, independent of cortical oscillation, and contributes to functional recovery. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10