Nasal Oxytocin for Social Deficits in Childhood Autism: A Randomized Controlled Trial

Autor/inn/en	Dadds, Mark R.; MacDonald, Elayne; Cauchi, Avril; Williams, Katrina; Levy, Florence; Brennan, John
Titel	Nasal Oxytocin for Social Deficits in Childhood Autism: A Randomized Controlled Trial
Quelle	In: Journal of Autism and Developmental Disorders, 44 (2014) 3, S.521-531 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-013-1899-3
Schlagwörter	Comparative Analysis; Experimental Groups; Control Groups; Drug Therapy; Social Behavior; Behavior Modification; Autism; Intervention; Males; Children; Adolescents; Pervasive Developmental Disorders; Child Behavior; Parent Attitudes; Observation; Symptoms (Individual Disorders); Interaction; Parent Child Relationship; Emotional Response; Clinical Diagnosis; Interpersonal Competence; Adjustment (to Environment) + Suchen Sie Ihr Suchwort? Social behaviour; Soziales Verhalten; Behaviour modification; Verhaltensänderung; Autismus; Male; Männliches Geschlecht; Child; Kind; Kinder; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Elternverhalten; Beobachtung; Psychiatrische Symptomatik; Interaktion; Parents-child relationship; Parent-child-relation; Parent-child relationship; Eltern-Kind-Beziehung; Emotionales Verhalten; Interpersonale Kompetenz
Abstract	The last two decades have witnessed a surge in research investigating the application of oxytocin as a method of enhancing social behaviour in humans. Preliminary evidence suggests oxytocin may have potential as an intervention for autism. We evaluated a 5-day "live-in" intervention using a double-blind randomized control trial. 38 male youths (7-16 years old) with autism spectrum disorders were administered 24 or 12 international units (depending on weight) intranasal placebo or oxytocin once daily over four consecutive days. The oxytocin or placebo was administered during parent-child interaction training sessions. Parent and child behaviours were assessed using parent reports, clinician ratings, and independent observations, at multiple time points to measure side-effects; social interaction skills; repetitive behaviours; emotion recognition and diagnostic status. Compared to placebo, intranasal oxytocin did not significantly improve emotion recognition, social interaction skills, or general behavioral adjustment in male youths with autism spectrum disorders. The results show that the benefits of nasal oxytocin for young individuals with autism spectrum disorders may be more circumscribed than suggested by previous studies, and suggest caution in recommending it as an intervention that is broadly effective. (As Provided).
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Update	2017/4/10