Gene-Environment Interactions in Genome-Wide Association Studies: Current Approaches and New Directions

Autor/inn/en	Winham, Stacey J.; Biernacka, Joanna M.
Titel	Gene-Environment Interactions in Genome-Wide Association Studies: Current Approaches and New Directions
Quelle	In: Journal of Child Psychology and Psychiatry, 54 (2013) 10, S.1120-1134 (15 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/jcpp.12114
Schlagwörter	Genetics; Research Methodology; Scientific Research; Environmental Influences; Personality Traits; Psychiatry; Mental Disorders; Correlation; Psychological Studies; Mental Health + Suchen Sie Ihr Suchwort? Humangenetik; Research method; Forschungsmethode; Environmental influence; Umwelteinfluss; Individual characteristics; Personality characteristic; Persönlichkeitsmerkmal; Psychiatrie; Mental illness; Geisteskrankheit; Korrelation; Psychohygiene
Abstract	Background: Complex psychiatric traits have long been thought to be the result of a combination of genetic and environmental factors, and gene-environment interactions are thought to play a crucial role in behavioral phenotypes and the susceptibility and progression of psychiatric disorders. Candidate gene studies to investigate hypothesized gene-environment interactions are now fairly common in human genetic research, and with the shift toward genome-wide association studies, genome-wide gene-environment interaction studies are beginning to emerge. Methods: We summarize the basic ideas behind gene-environment interaction, and provide an overview of possible study designs and traditional analysis methods in the context of genome-wide analysis. We then discuss novel approaches beyond the traditional strategy of analyzing the interaction between the environmental factor and each polymorphism individually. Results: Two-step filtering approaches that reduce the number of polymorphisms tested for interactions can substantially increase the power of genome-wide gene-environment studies. New analytical methods including data-mining approaches, and gene-level and pathway-level analyses, also have the capacity to improve our understanding of how complex genetic and environmental factors interact to influence psychologic and psychiatric traits. Such methods, however, have not yet been utilized much in behavioral and mental health research. Conclusions: Although methods to investigate gene-environment interactions are available, there is a need for further development and extension of these methods to identify gene-environment interactions in the context of genome-wide association studies. These novel approaches need to be applied in studies of psychology and psychiatry. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10