Making It Stick: A CURE Designed to Introduce Students to the Scientific Process and the Host Response to Foreign Materials

Autor/inn/en	Slee, Joshua B.; McLaughlin, Jacqueline S.
Titel	Making It Stick: A CURE Designed to Introduce Students to the Scientific Process and the Host Response to Foreign Materials
Quelle	In: Biochemistry and Molecular Biology Education, 47 (2019) 4, S.417-425 (9 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Slee, Joshua B.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1470-8175
DOI	10.1002/bmb.21248
Schlagwörter	Science Instruction; Science Process Skills; Cytology; Molecular Biology; Teaching Methods; Science Laboratories; Science Experiments + Suchen Sie Ihr Suchwort? Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Zytologie; Molekularbiologie; Teaching method; Lehrmethode; Unterrichtsmethode
Abstract	Often overlooked in many molecular cell biology laboratory and cell culture courses, suspension cells represent an important aspect of molecular cell biology and cell culture. Most primary cell cultures and cell lines are adherent cells which grow in monolayers on surfaces. However, other cells such as hematopoietic cells, certain tumor cells, and cells of the immune system are suspension cells which are anchorage-independent which grow and divide in solution. THP-1 cells are a commercially available, spontaneously immortalized monocyte-like cell line derived from the peripheral blood of a patient with acute monocytic leukemia. These cells are an excellent model for suspension cell culture and studies of the immune system. Researchers have used THP-1 cells to study the host response to implantable devices and biomaterials "in vitro." Tissue contacting surfaces of implantable materials initiate a host inflammatory response characterized by many events, one of which includes macrophage attachment to the surface, which ultimately leads to degradation and failure of the material. Using the THP-1 adhesion assay embedded in this CURE, students can participate in the scientific process by testing substances which may prevent the host inflammatory response to implantable devices and biomaterials. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01