Sex Differences in Fear Discrimination Do Not Manifest as Differences in Conditioned Inhibition

Autor/inn/en	Foilb, Allison R.; Bals, Julia; Sarlitto, Mary C.; Christianson, John P.
Titel	Sex Differences in Fear Discrimination Do Not Manifest as Differences in Conditioned Inhibition
Quelle	In: Learning & Memory, 25 (2018) 1, S.49-53 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.045500.117
Schlagwörter	Gender Differences; Posttraumatic Stress Disorder; Fear; Discrimination Learning; Safety; Inhibition; Summative Evaluation; Brain; Recall (Psychology); Animals + Suchen Sie Ihr Suchwort? Geschlechterkonflikt; Furcht; Lernen; Lernprozess; Sicherheit; Hemmung; Gehirn; Abberufung; Animal; Tier; Tiere
Abstract	Distinguishing safety from danger is necessary for survival, but is aberrant in individuals with post-traumatic stress disorder (PTSD). While PTSD is more prevalent in women than men, research on sex differences in safety learning is limited. Here, female rats demonstrated greater fear discrimination than males in a CS+/CS- paradigm. To determine if this sex difference transferred to fear inhibition, rats were tested for conditioned inhibition in a summation test with the CS+ and CS- presented in compound; no sex difference emerged. The results suggest sex differences in the neural mechanisms of discrimination learning but not recall of a fear inhibitor. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01