Inhibition of Estradiol Synthesis Impairs Fear Extinction in Male Rats

Autor/inn/en	Graham, Bronwyn M.; Milad, Mohammed R.
Titel	Inhibition of Estradiol Synthesis Impairs Fear Extinction in Male Rats
Quelle	In: Learning & Memory, 21 (2014) 7, S.347-350 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.034926.114
Schlagwörter	Inhibition; Fear; Learning Processes; Males; Animals; Biochemistry; Recall (Psychology) + Suchen Sie Ihr Suchwort? Hemmung; Furcht; Learning process; Lernprozess; Male; Männliches Geschlecht; Animal; Tier; Tiere; Biochemie; Abberufung
Abstract	Emerging research has demonstrated that the sex hormone estradiol regulates fear extinction in female rodents and women. Estradiol may also regulate fear extinction in males, given its role in synaptic plasticity in both sexes. Here we report that inhibition of estradiol synthesis during extinction training, via the aromatase inhibitor fadrozole, significantly impairs extinction recall in male rats. This deficit in extinction recall is not due to state-dependent memory formation and is completely abolished by coadministration of estradiol. Our data suggest that estradiol may be just as important in the regulation of fear extinction in males as it is in females. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10