Experiential Learning in Rodents: Past Experience Enables Rapid Learning and Localized Encoding in Hippocampus

Autor/inn/en	Cox, Conor D.; Palmer, Linda C.; Pham, Danielle T.; Trieu, Brian H.; Gall, Christine M.; Lynch, Gary
Titel	Experiential Learning in Rodents: Past Experience Enables Rapid Learning and Localized Encoding in Hippocampus
Quelle	In: Learning & Memory, 24 (2017) 11, S.569-579 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.045559.117
Schlagwörter	Animals; Experiential Learning; Brain; Short Term Memory; Long Term Memory; Animal Behavior; Laboratory Experiments; Science Experiments; Brain Hemisphere Functions + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Experiental learning; Erfahrungsorientiertes Lernen; Gehirn; Kurzzeitgedächtnis; Langzeitgedächtnis; Tierverhalten; Laboratory work; Laborarbeit
Abstract	Humans routinely use past experience with complexity to deal with novel, challenging circumstances. This fundamental aspect of real-world behavior has received surprisingly little attention in animal studies, and the underlying brain mechanisms are unknown. The present experiments tested for transfer from past experience in rats and then used quantitative imaging to localize synaptic modifications in hippocampus. Six daily exposures to an enriched environment (EE) caused a marked enhancement of short- and long-term memory encoded during a 30-min session in a different and complex environment relative to rats given extensive handling or access to running wheels. Relatedly, the EE animals investigated the novel environment in a different manner than the other groups, suggesting transfer of exploration strategies acquired in earlier interactions with complexity. This effect was not associated with changes in the number or size of excitatory synapses in hippocampus. Maps of synapses expressing a marker for long-term potentiation indicated that encoding in the EE group, relative to control animals, was concentrated in hippocampal field CA1. Importantly, <1% of the total population of synapses was involved in production of the regional map. These results constitute the first evidence that the transfer of experience profoundly affects the manner in which hippocampus encodes complex information. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01