Childhood Onset Schizophrenia: Cortical Brain Abnormalities as Young Adults

Autor/inn/en	Greenstein, Deanna; Lerch, Jason; Shaw, Philip; Clasen, Liv; Giedd, Jay; Gochman, Peter; Rapoport, Judith; Gogtay, Nitin
Titel	Childhood Onset Schizophrenia: Cortical Brain Abnormalities as Young Adults
Quelle	In: Journal of Child Psychology and Psychiatry, 47 (2006) 10, S.1003-1012 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/j.1469-7610.2006.01658.x
Schlagwörter	Schizophrenia; Symptoms (Individual Disorders); Neurology; Children; Young Adults; Patients; Brain; Longitudinal Studies; Child Health; Brain Hemisphere Functions; Severe Disabilities; Adolescents; Neurological Impairments; Neurological Organization + Suchen Sie Ihr Suchwort? Schizophrenie; Psychiatrische Symptomatik; Neurologie; Child; Kind; Kinder; Young adult; Junger Erwachsener; Patient; Gehirn; Longitudinal study; Longitudinal method; Longitudinal methods; Längsschnittuntersuchung; Severe disability; Schwerbehinderung; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Neurodegenerative Erkrankung
Abstract	Background: Childhood onset schizophrenia (COS) is a rare but severe form of the adult onset disorder. While structural brain imaging studies show robust, widespread, and progressive gray matter loss in COS during adolescence, there have been no longitudinal studies of sufficient duration to examine comparability with the more common adult onset illness. Methods: Neuro-anatomic magnetic resonance scans were obtained prospectively from ages 7 through 26 in 70 children diagnosed with COS and age and sex matched healthy controls. Cortical thickness was measured at 40,962 points across the cerebral hemispheres using a novel, fully automated, validated method. Patterns of patient-control differences in cortical development were compared over a 19-year period. Results: Throughout the age range, the COS group had significantly smaller mean cortical thickness compared to controls. However, the COS brain developmental trajectory appeared to normalize in posterior (parietal) regions, and remained divergent in the anterior regions (frontal and temporal) regions, and the pattern of loss became more like that seen in adults. Conclusions: Cortical thickness loss in COS appears to localize with age to prefrontal and temporal regions that are seen for both medication naive and medicated adult onset patients. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10