Nobel Chemistry in the Laboratory: Synthesis of a Ruthenium Catalyst for Ring-Closing Olefin Metathesis--An Experiment for the Advanced Inorganic or Organic Laboratory

Autor/in	Greco, George E.
Titel	Nobel Chemistry in the Laboratory: Synthesis of a Ruthenium Catalyst for Ring-Closing Olefin Metathesis--An Experiment for the Advanced Inorganic or Organic Laboratory
Quelle	In: Journal of Chemical Education, 84 (2007) 12, S.1995-1997 (3 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
Schlagwörter	Chemistry; Laboratories; Experiments; Undergraduate Students; Higher Education; Organic Chemistry + Suchen Sie Ihr Suchwort? Chemie; Laboratory; Laboratorium; Erprobung; Hochschulbildung; Hochschulsystem; Hochschulwesen; Organische Chemie
Abstract	An experiment for the upper-level undergraduate laboratory is described in which students synthesize a ruthenium olefin metathesis catalyst, then use the catalyst to carry out the ring-closing metathesis of diethyl diallylmalonate. The olefin metathesis reaction was the subject of the 2005 Nobel Prize in chemistry. The catalyst chosen for this experiment is the ruthenium alkylidene complex that is most practical to synthesize in an undergraduate laboratory for reasons of time, safety, and cost of materials. The three-step synthesis of (PCy[subscript 3])[subscript 2]Cl[subscript 2]Ru(=CH-CH=CMe[subscript 2]) from RuCl[subscript 3] multiplied by H[subscript 2]O goes through [(COD)RuCl[subscript 2]][subscript x] and Ru(H)(H[subscript 2])(Cl)(PCy[subscript 3])[subscript 2] as intermediates. The latter complex is air sensitive, giving students the opportunity to learn Schlenk techniques. The ring-closed product is purified by column chromatography, and the catalyst and the ring-closed product are characterized by NMR spectroscopy. (Contains 2 figures, 2 schemes, and 1 table.) (As Provided).
Anmerkungen	Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail: jchemed@egpp.com; Web site: http://www.jce.divched.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10