Literaturnachweis - Detailanzeige
Autor/inn/en | Hellings, Jessica A.; Zarcone, Jennifer R.; Reese, R. Matthew; Valdovinos, Maria G.; Marquis, Janet G.; Fleming, Kandace K.; Schroeder, Stephen R. |
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Titel | A Crossover Study of Risperidone in Children, Adolescents and Adults with Mental Retardation |
Quelle | In: Journal of Autism and Developmental Disorders, 36 (2006) 3, S.401-411 (11 Seiten)
PDF als Volltext |
Sprache | englisch |
Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
ISSN | 0162-3257 |
DOI | 10.1007/s10803-006-0078-1 |
Schlagwörter | Drug Therapy; Mental Retardation; Pervasive Developmental Disorders; Children; Adolescents; Adults; Pharmacology; Behavior Disorders; Body Weight; Measures (Individuals); Aggression; Aberrant Behavior Checklist |
Abstract | Risperidone has shown safety and efficacy for aggressive and destructive behaviors in short-term studies. This longer-duration study includes a broad sample. Forty subjects, aged 8-56 years (mean=22), all with mental retardation and 36 with autism spectrum disorders participated in this 22-week crossover study, with 24 weeks of open maintenance thereafter. Of 40 subjects, 23 (57.5%) responded fully (50% decrease in Aberrant Behavior Checklist-Community Irritability subscale score), while 35 subjects (87.5%) showed a 25% decrease. Gender, mood disorder, and antiseizure medications did not alter response. Increased appetite and weight gain were common. Low dose risperidone was effective for aggressive behavior in persons with MR. More long-term studies are needed, incorporating weight control interventions. (Author). |
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Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
Update | 2017/4/10 |