The Development of Mental Health Difficulties in Young People with and without Developmental Language Disorder: A Gene-Environment Interplay Study Using Polygenic Scores

Autor/inn/en	Toseeb, Umar; Vincent, John; Oginni, Olakunle A.; Asbury, Kathryn; Newbury, Dianne F.
Titel	The Development of Mental Health Difficulties in Young People with and without Developmental Language Disorder: A Gene-Environment Interplay Study Using Polygenic Scores
Quelle	In: Journal of Speech, Language, and Hearing Research, 66 (2023) 5, S.1639-1657 (19 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Toseeb, Umar) ORCID (Oginni, Olakunle A.) ORCID (Asbury, Kathryn) ORCID (Newbury, Dianne F.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1092-4388
Schlagwörter	Developmental Delays; Language Impairments; Mental Health; Genetics; Environmental Influences; Mental Disorders; Children; Adolescents; Depression (Psychology); Anxiety Disorders; Attention Deficit Hyperactivity Disorder; Predictor Variables; Socioeconomic Status; Family Environment; Foreign Countries; United Kingdom (England); Strengths and Difficulties Questionnaire + Suchen Sie Ihr Suchwort? Entwicklungsverzögerung; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech handicap; Speech handicaps; Speech impairment; Speech impairments; Language handicaps; Sprachbehinderung; Psychohygiene; Humangenetik; Environmental influence; Umwelteinfluss; Mental illness; Geisteskrankheit; Child; Kind; Kinder; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Prädiktor; Socio-economic status; Sozioökonomischer Status; Familienmilieu; Ausland
Abstract	Purpose: Young people with developmental language disorder (DLD) have poorer mental health than those without DLD. However, not all young people with DLD are equally affected; some have more mental health difficulties than others. What explains these differences remains unclear. Method: Data from a community cohort study, the Avon Longitudinal Study of Parents and Children, were analyzed to investigate genetic and environmental influences on the development of mental health difficulties at five time points from childhood (7 years) to adolescence (16 years) in 6,387 young people (8.7% with DLD). Regression and latent class models were fitted to the data. Results: Polygenic scores (PGSs), indices of genetic risk, for common psychiatric disorders (major depressive disorder, anxiety disorder, and attention deficit hyperactivity disorder) predicted mental health difficulties in both groups (with and without DLD). The presence of DLD, in some instances, amplified mental health difficulties for those with high genetic risk for common psychiatric disorders. Subgroups of children with similar developmental trajectories of mental health difficulties were identified. Young people with DLD were more likely than those without DLD to follow mental health subgroups characterized by consistently high levels of difficulties during development. PGSs, socioeconomic status, and the early home environment distinguished subgroups with low mental health difficulties from those characterized by high levels of difficulties, but these effects did not differ based on DLD status. Conclusions: These findings suggest that, for the most part, both genetic and environmental risk affect the development of mental health difficulties in a cumulative way for young people with DLD (and those without). Some analysis did, however, suggest that genetic risk for common psychiatric disorders might manifest more strongly in those with DLD compared with those without DLD. (As Provided).
Anmerkungen	American Speech-Language-Hearing Association. 2200 Research Blvd #250, Rockville, MD 20850. Tel: 301-296-5700; Fax: 301-296-8580; e-mail: slhr@asha.org; Web site: http://jslhr.pubs.asha.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01