metaCOVID: A Web-Application for Living Meta-Analyses of COVID-19 Trials

Autor/inn/en	Evrenoglou, Theodoros; Boutron, Isabelle; Seitidis, Georgios; Ghosn, Lina; Chaimani, Anna
Titel	metaCOVID: A Web-Application for Living Meta-Analyses of COVID-19 Trials
Quelle	In: Research Synthesis Methods, 14 (2023) 3, S.479-488 (10 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Evrenoglou, Theodoros) ORCID (Boutron, Isabelle) ORCID (Seitidis, Georgios) ORCID (Ghosn, Lina) ORCID (Chaimani, Anna)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1759-2879
DOI	10.1002/jrsm.1627
Schlagwörter	COVID-19; Pandemics; Meta Analysis; Computer Oriented Programs; Randomized Controlled Trials; Medical Research; Medical Services + Suchen Sie Ihr Suchwort? Meta-analysis; Metaanalyse; Computerprogramm; Arzt
Abstract	Outputs from living evidence syntheses projects have been used widely during the pandemic by guideline developers to form evidence-based recommendations. However, the needs of different stakeholders cannot be accommodated by solely providing pre-defined non amendable numerical summaries. Stakeholders also need to understand the data and perform their own exploratory analyses. This requires resources, time, statistical expertise, software knowledge as well as relevant clinical expertise to avoid spurious conclusions. To assist them, we created the "metaCOVID" application which, based on automation processes, facilitates the fast exploration of the data and the conduct of sub-analyses tailored to end-users needs. "metaCOVID" has been created in R and is freely available as an R-Shiny application. Based on the COVID-NMA platform (https://covid-nma.com/) the application conducts living meta-analyses of randomized controlled trials related to COVID-19 treatments and vaccines for several outcomes. Several options are available for subgroup and sensitivity analyses. The results are presented in downloadable forest plots. We illustrate "metaCOVID" through three examples involving well-known treatments and vaccines for COVID-19. The application is freely available from https://covid-nma.com/metacovid/. (As Provided).
Anmerkungen	Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01