Forget the Stress: Retrograde Amnesia for the Stress-Induced Impairment of Extinction Retrieval

Autor/inn/en	Briggs, James F.; McMullen, Kaitlyn M.
Titel	Forget the Stress: Retrograde Amnesia for the Stress-Induced Impairment of Extinction Retrieval
Quelle	In: Learning & Memory, 27 (2020) 5, S.173-176 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.051078.119
Schlagwörter	Memory; Stress Variables; Animals; Learning Processes; Intervention; Drug Therapy + Suchen Sie Ihr Suchwort? Gedächtnis; Animal; Tier; Tiere; Learning process; Lernprozess
Abstract	We investigated whether cycloheximide (CHX) would induce amnesia for the stress-induced impairment of extinction retrieval. First, a single restraint stress session was demonstrated to impair extinction retrieval, but not fear conditioning. A second experiment showed that when CHX was administered immediately after restraint, rats exhibited significant extinction retrieval at test (i.e., retrograde amnesia for the stress). In a third experiment, the stress session impaired various amounts of extinction durations, suggesting that the stress inhibited extinction retrieval rather than enhancing the original fear learning. These results suggest memories for acute stress are susceptible to disruption, which could have clinical implications. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01