Literaturnachweis - Detailanzeige
| Autor/inn/en | Hegarty, John P., II; Weber, Dylan J.; Cirstea, Carmen M.; Beversdorf, David Q. |
|---|---|
| Titel | Cerebro-Cerebellar Functional Connectivity Is Associated with Cerebellar Excitation-Inhibition Balance in Autism Spectrum Disorder |
| Quelle | In: Journal of Autism and Developmental Disorders, 48 (2018) 10, S.3460-3473 (14 Seiten)
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| Zusatzinformation | ORCID (Hegarty, John P., II) |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 0162-3257 |
| DOI | 10.1007/s10803-018-3613-y |
| Schlagwörter | Brain Hemisphere Functions; Diagnostic Tests; Autism; Pervasive Developmental Disorders; Correlation; Adolescents; Adults; Control Groups; Experimental Groups; Biochemistry; Listening Comprehension; Spectroscopy |
| Abstract | Atypical functional connectivity (FC) and an imbalance of excitation-to-inhibition (E/I) have been previously reported in cerebro-cerebellar circuits in autism spectrum disorder (ASD). The current investigation used resting state fMRI and proton magnetic resonance spectroscopy ([superscript 1]H-MRS) to examine the relationships between E/I (glutamate + glutamine/GABA) and FC of the dorsolateral prefrontal cortex and posterolateral cerebellar hemisphere from 14 adolescents/adults with ASD and 12 age/sex/IQ-matched controls. In this pilot sample, cerebro-cerebellar FC was positively associated with cerebellar E/I and listening comprehension abilities in individuals with ASD but not controls. Additionally, a subgroup of individuals with ASD and low FC (n = 5) exhibited reduced E/I and impaired listening comprehension. Thus, altered functional coherence of cerebro-cerebellar circuits in ASD may be related with a cerebellar E/I imbalance. (As Provided). |
| Anmerkungen | Springer. Available from: Springer Nature. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/ |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2020/1/01 |
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