The L-Type Voltage-Gated Calcium Channel Ca [subscript V] 1.2 Mediates Fear Extinction and Modulates Synaptic Tone in the Lateral Amygdala

Autor/inn/en	Temme, Stephanie J.; Murphy, Geoffrey G.
Titel	The L-Type Voltage-Gated Calcium Channel Ca [subscript V] 1.2 Mediates Fear Extinction and Modulates Synaptic Tone in the Lateral Amygdala
Quelle	In: Learning & Memory, 24 (2017) 11, S.580-588 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Fear; Brain Hemisphere Functions; Animals; Anxiety; Learning Processes; Conditioning + Suchen Sie Ihr Suchwort? Furcht; Animal; Tier; Tiere; Angst; Learning process; Lernprozess
Abstract	L-type voltage-gated calcium channels (LVGCCs) have been implicated in both the formation and the reduction of fear through Pavlovian fear conditioning and extinction. Despite the implication of LVGCCs in fear learning and extinction, studies of the individual LVGCC subtypes, Ca[subscript V]1.2 and Ca[subscript V] 1.3, using transgenic mice have failed to find a role of either subtype in fear extinction. This discontinuity between the pharmacological studies of LVGCCs and the studies investigating individual subtype contributions could be due to the limited neuronal deletion pattern of the Ca[subscript V]1.2 conditional knockout mice previously studied to excitatory neurons in the forebrain. To investigate the effects of deletion of Ca[subscript V]1.2 in all neuronal populations, we generated Ca [subscript V]1.2 conditional knockout mice using the synapsin1 promoter to drive Cre recombinase expression. Pan-neuronal deletion of Ca[subscript V]1.2 did not alter basal anxiety or fear learning. However, pan-neuronal deletion of Ca[subscript V]1.2 resulted in a significant deficit in extinction of contextual fear, implicating LVGCCs, specifically Ca[subscript V]1.2, in extinction learning. Further exploration on the effects of deletion of Ca[subscript V]1.2 on inhibitory and excitatory input onto the principle neurons of the lateral amygdala revealed a significant shift in inhibitory/excitatory balance. Together these data illustrate an important role of Ca[subscript V]1.2 in fear extinction and the synaptic regulation of activity within the amygdala. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01