Role of Proteasome-Dependent Protein Degradation in Long-Term Operant Memory in "Aplysia"

Autor/inn/en	Lyons, Lisa C.; Gardner, Jacob S.; Gandour, Catherine E.; Krishnan, Harini C.
Titel	Role of Proteasome-Dependent Protein Degradation in Long-Term Operant Memory in "Aplysia"
Quelle	In: Learning & Memory, 24 (2017) 1, S.59-64 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.043794.116
Schlagwörter	Memory; Biochemistry; Brain Hemisphere Functions; Role; Genetics; Drug Therapy; Molecular Structure; Operant Conditioning; Learning Processes; Animals + Suchen Sie Ihr Suchwort? Gedächtnis; Biochemie; Rollen; Humangenetik; Operante Konditionierung; Learning process; Lernprozess; Animal; Tier; Tiere
Abstract	We investigated the in vivo role of protein degradation during intermediate (ITM) and long-term memory (LTM) in "Aplysia" using an operant learning paradigm. The proteasome inhibitor MG-132 inhibited the induction and molecular consolidation of LTM with no effect on ITM. Remarkably, maintenance of steady-state protein levels through inhibition of protein synthesis using either anisomycin or rapamycin in conjunction with proteasome inhibition permitted the formation of robust 24 h LTM. Our studies suggest a primary role for proteasomal activity in facilitation of gene transcription for LTM and raise the possibility that synaptic mechanisms are sufficient to sustain 24 h memory. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01