Immediate-Release Methylphenidate for ADHD in Children with Comorbid Chronic Multiple Tic Disorder

Autor/inn/en	Gadow, Kenneth D.; Sverd, Jeffrey; Nolan, Edith E.; Sprafkin, Joyce; Schneider, Jayne
Titel	Immediate-Release Methylphenidate for ADHD in Children with Comorbid Chronic Multiple Tic Disorder
Quelle	In: Journal of the American Academy of Child & Adolescent Psychiatry, 46 (2007) 7, S.840-848 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0890-8567
DOI	10.1097/chi.0b013e31805c0860
Schlagwörter	Neurological Impairments; Attention Deficit Hyperactivity Disorder; Anxiety Disorders; Rating Scales; Patients; Severity (of Disability); Safety; Drug Therapy; Children; Observation; Outcomes of Treatment; Teacher Attitudes; Physicians; Parent Attitudes + Suchen Sie Ihr Suchwort? Neurodegenerative Erkrankung; Rating-Skala; Patient; Schweregrad; Sicherheit; Child; Kind; Kinder; Beobachtung; Lehrerverhalten; Physician; Doctor; Arzt; Elternverhalten
Abstract	Objective: To examine the safety and efficacy of immediate-release methylphenidate (MPH-IR) for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children (ages 6-12 years) with Tourette's syndrome (96%) or chronic motor tic disorder (4%). Method: Two cohorts of prepubertal children (N = 71) received placebo and three doses of MPH (0.1, 0.3, and 0.5 mg/kg) twice daily for 2 weeks each, under double-blind conditions as part of their involvement in a long-term observation study (1989-2004). Treatment effects were assessed with an extensive battery of parent-, teacher-, child-, and physician-completed rating scales and laboratory tasks. Results: MPH-IR effectively suppressed ADHD, oppositional defiant disorder, and peer aggression behaviors. There was no evidence that MPH-IR altered the overall severity of tic disorder or obsessive-compulsive disorder behaviors. Teacher ratings indicated that MPH-IR therapy decreased tic frequency and severity. Conclusions: MPH-IR appears to be a safe and effective short-term treatment for ADHD in the majority of children with chronic tic disorder; nevertheless, the possibility of tic exacerbation in susceptible individuals warrants careful monitoring of all patients. (Contains 4 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10