The Role of the Gustatory Cortex in Incidental Experience-Evoked Enhancement of Later Taste Learning

Autor/inn/en	Flores, Veronica L.; Parmet, Tamar; Mukherjee, Narendra; Nelson, Sacha; Katz, Donald B.; Levitan, David
Titel	The Role of the Gustatory Cortex in Incidental Experience-Evoked Enhancement of Later Taste Learning
Quelle	In: Learning & Memory, 25 (2018) 11, S.587-600 (14 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.048181.118
Schlagwörter	Sensory Experience; Memory; Incidental Learning; Neurology; Biology; Brain; Associative Learning + Suchen Sie Ihr Suchwort? Sinnerfahrung; Gedächtnis; Inzidentelles Lernen; Neurologie; Biologie; Gehirn
Abstract	The strength of learned associations between pairs of stimuli is affected by multiple factors, the most extensively studied of which is prior experience with the stimuli themselves. In contrast, little data is available regarding how experience with "incidental" stimuli (independent of any conditioning situation) impacts later learning. This lack of research is striking given the importance of incidental experience to survival. We have recently begun to fill this void using conditioned taste aversion (CTA), wherein an animal learns to avoid a taste that has been associated with malaise. We previously demonstrated that incidental exposure to salty and sour tastes (taste preexposure--TPE) enhances aversions learned later to sucrose. Here, we investigate the neurobiology underlying this phenomenon. First, we use immediate early gene (c-Fos) expression to identify gustatory cortex (GC) as a site at which TPE specifically increases the neural activation caused by taste-malaise pairing (i.e., TPE did not change c-Fos induced by either stimulus in isolation). Next, we use site-specific infection with the optical silencer Archaerhodopsin-T to show that GC inactivation during TPE inhibits the expected enhancements of both learning and CTA-related c-Fos expression, a full day later. Thus, we conclude that GC is almost certainly a vital part of the circuit that integrates incidental experience into later associative learning. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01