Common Infections with Polyomaviruses and Herpesviruses and Neuropsychological Development at 4 Years of Age, the Rhea Birth Cohort in Crete, Greece

Autor/inn/en	Karachaliou, Marianna; Chatzi, Leda; Roumeliotaki, Theano; Kampouri, Mariza; Kyriklaki, Andriani; Koutra, Katerina; Chalkiadaki, Georgia; Michel, Angelika; Stiakaki, Eftichia; Kogevinas, Manolis; Pawlita, Michael; Waterboer, Tim; de Sanjose, Silvia
Titel	Common Infections with Polyomaviruses and Herpesviruses and Neuropsychological Development at 4 Years of Age, the Rhea Birth Cohort in Crete, Greece
Quelle	In: Journal of Child Psychology and Psychiatry, 57 (2016) 11, S.1268-1276 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/jcpp.12582
Schlagwörter	Diseases; Neuropsychology; Cognitive Ability; Biochemistry; Behavior Problems; Child Behavior; Questionnaires; Screening Tests; Case Studies; Attention Deficit Hyperactivity Disorder; Diagnostic Tests; Cognitive Development; Preschool Children; Foreign Countries; Brain; Multiple Regression Analysis; Correlation; Scores; Child Development; Greece; McCarthy Scales of Childrens Abilities; Strengths and Difficulties Questionnaire + Suchen Sie Ihr Suchwort? Disease; Krankheit; Neuropsychologie; Denkfähigkeit; Biochemie; Fragebogen; Screening-Verfahren; Case study; Fallstudie; Case Study; Diagnostic test; Diagnostischer Test; Kognitive Entwicklung; Pre-school age; Preschool age; Child; Children; Pre-school education; Preschool education; Vorschulalter; Kind; Kinder; Vorschulkind; Vorschulkinder; Vorschulerziehung; Vorschule; Ausland; Gehirn; Korrelation; Kindesentwicklung; Griechenland
Abstract	Background: Viral infections of the central nervous system may have detrimental effects for the developing brain, but the effects of less virulent common infections are unclear. We aim to investigate the impact of common viral infections of early childhood on neuropsychological performance of children at age four. Methods: We used cross-sectional data on 674 children participating at the 4 years of age follow-up of the Rhea birth cohort in Crete, Greece. Blood levels of IgG antibodies to 10 polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses [Epstein-Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1), and herpes simplex virus-2 (HSV-2)] were measured using multiplex serology. Child's neuropsychological development at age four was assessed using the McCarthy Scales of Children's Abilities, the Attention-Deficit Hyperactivity Disorder Test (ADHDT), and the Strengths and Difficulties Questionnaire (SDQ). Multiple linear regression models were used to explore the associations. Results: Seroprevalence to polyomaviruses ranged from 21% for HPyV9 to 82% for HPyV10. Seroprevalence for EBV was 53%, for CMV 26%, for HSV-1 3.6%, and for HSV-2 1.5%. Children seropositive to =8 polyomaviruses had lower score in ADHDT inattention subscale [ß = -1.28 (95% CI: -2.56, -0.001)] and lower score in SDQ hyperactivity-inattention subscale [ß = -0.99 (95% CI: -1.60, -0.37)] versus children seropositive to =3 polyomaviruses. Seropositivity to BKPyV, a potential neurotropic virus, was associated with higher score in ADHDT inattention subscale [ß = 0.87 (95% CI: 0.03, 1.71)]. Conclusions: These findings suggest that acquisition of polyomaviruses during development may influence behavioral outcomes in early childhood. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01