Finger Tapping-Related Activation Differences in Treatment-Naive Pediatric Tourette Syndrome: A Comparison of the Preferred and Nonpreferred Hand

Autor/inn/en	Roessner, Veit; Wittfoth, Matthias; August, Julia M.; Rothenberger, Aribert; Baudewig, Jurgen; Dechent, Peter
Titel	Finger Tapping-Related Activation Differences in Treatment-Naive Pediatric Tourette Syndrome: A Comparison of the Preferred and Nonpreferred Hand
Quelle	In: Journal of Child Psychology and Psychiatry, 54 (2013) 3, S.273-279 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/j.1469-7610.2012.02584.x
Schlagwörter	Neurological Impairments; Foreign Countries; Males; Early Adolescents; Preadolescents; Brain Hemisphere Functions; Diagnostic Tests; Human Body; Motion; Attention Deficit Hyperactivity Disorder; Symptoms (Individual Disorders); Handedness; Severity (of Disability); Comparative Analysis; Correlation; Behavior Disorders; Hypothesis Testing; Observation; Semi Structured Interviews; Germany; Edinburgh Handedness Inventory; Strengths and Difficulties Questionnaire; Wechsler Intelligence Scale for Children + Suchen Sie Ihr Suchwort? Neurodegenerative Erkrankung; Ausland; Male; Männliches Geschlecht; Pre-adolescence; Präadoleszenz; Diagnostic test; Diagnostischer Test; Menschlicher Körper; Bewegungsablauf; Psychiatrische Symptomatik; Linkshändigkeit; Schweregrad; Korrelation; Hypothesenprüfung; Hypothesentest; Beobachtung; Deutschland
Abstract	Background: Disturbances of motor circuitry are commonly encountered in Tourette syndrome (TS). The aim of this study was to investigate simple motor performance differences between boys with TS and healthy controls. Methods: We attempted to provide insight into motor network alterations by studying a group of treatment-naive patients suffering from "pure" TS, i.e., without comorbid symptomatology at an early stage of disease. We used functional MRI to compare activation patterns during right (preferred) and left (nonpreferred) index finger tapping between 22 TS boys (12.6 plus/minus 1.7 years) and 22 age-matched healthy control boys. Results: Boys with TS revealed altered motor network recruitment for right (dominant) and left (nondominant) index finger tapping. Brain activation patterns in response to index finger tapping of the nonpreferred left hand reflected the most prominent differences, including activation decrease in contralateral sensorimotor cortex while recruiting premotor and prefrontal regions along with the left inferior parietal lobule to a greater extent. Conclusions: This study demonstrates clear functional differences of simple index finger tapping in early-stage TS. We suggest that this reflects the requirement for additional brain networks to keep a normal performance level during the actual task and adaptive mechanisms due to continuous tic suppression and performance in TS. (Contains 2 tables and 1 figure.) (As Provided).
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Update	2017/4/10