A Hybrid Approach for Translational Research

Autor/in	Webster, Yue Wang
Titel	A Hybrid Approach for Translational Research
Quelle	(2010), (70 Seiten) PDF als Volltext Verfügbarkeit Ph.D. Dissertation, Indiana University
Sprache	englisch
Dokumenttyp	gedruckt; online; Monographie
ISBN	978-1-1240-6125-2
Schlagwörter	Hochschulschrift; Dissertation; Diseases; Social Networks; Therapy; Medical Research; Research Methodology; Scientific Research; Databases; Medicine; Cancer; Genetics; Knowledge Management + Suchen Sie Ihr Suchwort? Thesis; Dissertations; Academic thesis; Disease; Krankheit; Social network; Soziales Netzwerk; Therapie; Research method; Forschungsmethode; Datenbank; Medizin; Carcinoma; Karzinom; Krebs (med); Krebserkrankung; Humangenetik; Wissensmanagement
Abstract	Translational research has proven to be a powerful process that bridges the gap between basic science and medical practice. The complexity of translational research is two-fold: integration of vast amount of information in disparate silos, and dissemination of discoveries to stakeholders with different interests. We designed and implemented a hybrid knowledge discovery framework. We developed strategies to leverage both traditional biomedical databases and Health Social Network Communities content in the discovery process. Heuristic and quantitative evaluations were carried out in Colorectal Cancer and Amyotrophic Lateral Sclerosis disease areas. The results demonstrate the potential of our approach to bridge silos and to identify hidden links among clinical observations, drugs, genes and diseases, which may eventually lead to the discovery of novel disease targets, biomarkers and therapies. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.] (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10