Psychotropic Medication Use among Children with Autism Spectrum Disorders within the Simons Simplex Collection: Are Core Features of Autism Spectrum Disorder Related?

Autor/inn/en	Mire, Sarah S.; Nowell, Kerri P.; Kubiszyn, Thomas; Goin-Kochel, Robin P.
Titel	Psychotropic Medication Use among Children with Autism Spectrum Disorders within the Simons Simplex Collection: Are Core Features of Autism Spectrum Disorder Related?
Quelle	In: Autism: The International Journal of Research and Practice, 18 (2014) 8, S.933-942 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1362-3613
DOI	10.1177/1362361313498518
Schlagwörter	Drug Therapy; Children; Autism; Pervasive Developmental Disorders; Symptoms (Individual Disorders); Adolescents; Incidence; Correlation; Age Differences; Cognitive Ability; Regression (Statistics); Predictor Variables; Attention Deficit Hyperactivity Disorder; Antisocial Behavior; Behavior Problems; Foreign Countries; Interviews; Parents; North America; Mullen Scales of Early Learning; Autism Diagnostic Observation Schedule; Wechsler Intelligence Scale for Children + Suchen Sie Ihr Suchwort? Child; Kind; Kinder; Autismus; Psychiatrische Symptomatik; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Vorkommen; Korrelation; Age; Difference; Age difference; Altersunterschied; Denkfähigkeit; Regression; Regressionsanalyse; Prädiktor; Ausland; Interviewing; Interviewtechnik; Eltern; Nordamerika
Abstract	Psychotropic medication use and its relationship to autism spectrum core features were examined in a well-characterized but nonstratified North American sample (N = 1605) of children/adolescents diagnosed with autism spectrum disorders utilizing the "Autism Diagnostic Observation Schedule" and the "Autism Diagnostic Interview-Revised," from the multisite Simons Simplex Collection. Analyses included (a) prevalence of psychotropic use (overall, and by classes), (b) correlations between prevalence of use and autism spectrum core features, age, and cognitive functioning, and (c) logistic regression to identify whether these factors were predictive of psychotropic use. Results indicated 41.7% ever used one or more classes of psychotropic medications, with attention deficit hyperactivity disorder medications used most. Small but significant correlations between psychotropic medication use and (a) social impairment (p < 0.001) and (b) repetitive behaviors (p < 0.001) were found. Overall, however, autism spectrum disorder core features are weakly related to medication use. Older children used more psychotropics (p < 0.001), and higher cognitive functioning was associated with less overall psychotropic use (p < 0.001). Logistic regression indicated that use of psychotropics was predicted by repetitive behaviors (both clinician-observed and parent-reported), age, and cognitive ability level. Limitations inherent to the Simons Simplex Collection sample, methodology, and the correlational analyses are discussed. Directions for future research include investigation of factors more influential than core symptoms on psychotropic treatment (e.g. parent perceptions, comorbid symptoms). (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10