Literaturnachweis - Detailanzeige
| Autor/inn/en | Ashby, F. Gregory; Crossley, Matthew J. |
|---|---|
| Titel | A Computational Model of How Cholinergic Interneurons Protect Striatal-Dependent Learning |
| Quelle | In: Journal of Cognitive Neuroscience, 23 (2011) 6, S.1549-1566 (18 Seiten)
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| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 0898-929X |
| DOI | 10.1162/jocn.2010.21523 |
| Schlagwörter | Rewards; Educational Environment; Models; Computation; Theories; Learning Processes; Neurological Organization; Neurology; Science Education; Biology; Skill Development; Brain; Inhibition; Behavior; Cognitive Psychology |
| Abstract | An essential component of skill acquisition is learning the environmental conditions in which that skill is relevant. This article proposes and tests a neurobiologically detailed theory of how such learning is mediated. The theory assumes that a key component of this learning is provided by the cholinergic interneurons in the striatum known as tonically active neurons (TANs). The TANs are assumed to exert a tonic inhibitory influence over cortical inputs to the striatum that prevents the execution of any striatal-dependent actions. The TANs learn to pause in rewarding environments, and this pause releases the striatal output neurons from this inhibitory effect, thereby facilitating the learning and expression of striatal-dependent behaviors. When rewards are no longer available, the TANs cease to pause, which protects striatal learning from decay. A computational version of this theory accounts for a variety of single-cell recording data and some classic behavioral phenomena, including fast reacquisition after extinction. (As Provided). |
| Anmerkungen | MIT Press. 55 Hayward Street, Cambridge, MA 02142. Tel: 617-253-2889; Fax: 617-253-1709; e-mail: journals-orders@mit.edu; Web site: http://www.mitpressjournals.org/loi/jocn |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2017/4/10 |
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